[ Special Issue : Seoul Tech Capstone Design ]

Journal of the Korean Society of Manufacturing Technology Engineers - Vol. 27, No. 3, pp.300-305

ISSN: 2508-5107 (Online)

Print publication date 15 Jun 2018

Received 16 Mar 2018 Revised 30 Apr 2018 Accepted 06 May 2018

DOI: https://doi.org/10.7735/ksmte.2018.27.3.300

휴대용 랩온어칩을 위한 무동력 펌프 제작

최윤정^a ; 지현영^a ; 조영학^a^{, *}

Fabrication of Finger-squeezing Pump for Portable Lab-on-a-chip

Yun Jung Choi^a ; Hyoung Young Ji^a ; Young Hak Cho^a^{, *}

aDept. of Mechanical System Design Engineering, Seoul National University of Science and Technology, 232, Gongneung-ro, Nowon-gu, Seoul 01811, Korea

Correspondence to: ^*Tel.: +82-2-970-6351, Fax: +82-2-974-8270, E-mail address: ycho@seoultech.ac.kr (Young Hak Cho).

Abstract

We fabricated two types of finger-squeezing pumps that were integrated with a lab-on-a-chip. One was a check-valve-type pump that comprised two check valves and one pump reservoir in between, which was operated by the deformable PDMS (Polydimethylsiloxane) membrane of the check valves. The other was a PDMS-sponge-type pump that was operated by the deformation of a porous PDMS sponge. The porous PDMS sponge could be fabricated by the sugar leaching technique based on the capillary suction of pre-cured PDMS into sugar lumps. Three kinds of PDMS-sponge-type pumps were fabricated; all had different porosities owing to the different sugar grain sizes. The performance of the check-valve-type pump and the three types of PDMS-sponge-type pumps were investigated. They were integrated with microfluidic chips to detect the fluorescence of microalgae. The microfluidic chips integrated with finger-squeezing pumps are expected to be portable, disposable, and power-free chips.

Keywords:

Finger-squeezing pump, Lab-on-a-chip, PDMS membrane, Check-valve, Porous PDMS sponge

Acknowledgments

이 연구는 서울과학기술대학교 교내연구비의 지원으로 수행되었습니다.

References

Sista, R., Hua, Z., Thwar, P., Sudarsan, A., Srinivasan, V., Eckhardt, A., Pollack, M., Pamula, V., 2008, Development of a Digital Microfluidic Platform for Point of Care Testing, Lab on a Chip, 8 2091-2104. [https://doi.org/10.1039/b814922d]
Samborski, A., Jankowski, P., Wegrzyn, J., Michalski, J. A., Pawłowska, S., Jakieła, S., Garstecki, P., 2015, Blood Diagnostics Using Sedimentation to Extract Plasma on a Fully Integrated Point-of-care Microfluidic System, Eng. Life Sci., 15 333-339. [https://doi.org/10.1002/elsc.201400077]
Shin, Y. -H., Barnett, J. Z., Song, E., Gutierrez-Wing, M. T., Rusch, K. A., Choi, J. -W., 2015, A Portable Fluorescent Sensor for On-site Detection of Microalgae, Microelectronic Engineering, 144 6-11. [https://doi.org/10.1016/j.mee.2015.01.005]
Iverson, B. D., Garimella, S. V., 2008, Recent Advances in Microscale Pumping Technologies: A Review and Evaluation, Microfluid. Nanofluid., 5 145-174. [https://doi.org/10.1007/s10404-008-0266-8]
Li, W., Chen, T., Chen, Z., Fei, P., Yu, Z., Pang, Y., Huang, Y., 2012, Squeeze-chip: A Finger-controlled Microfluidic Flow Network Device and its Application to Biochemical Assays, Lab on a Chip, 12 1587-1590. [https://doi.org/10.1039/c2lc40125h]
Cha, K. J., Kim, D. S., 2011, A Portable Pressure Pump for Microfluidic Lab-on-a-chip Systems Using a Porous Polydimethylsiloxane (PDMS) Sponge, Biomedical Microdevices, 13 877-883. [https://doi.org/10.1007/s10544-011-9557-z]
Gong, M. M., MacDonald, B. D., Nguyen, T. V., Sinton, D., 2011, Hand-powered Microfluidics: A Membrane Pump with a Patient-to-chip Syringe Interface, Biomicrofluidics, 6 044102. [https://doi.org/10.1063/1.4762851]
Xu, L., Lee, H., Jetta, D., Oh, K. W., 2015, Vacuum-driven Power-free Microfluidics Utilizing the Gas Solubility or Permeability of Polydimethylsiloxane (PDMS), Lab on a Chip, 15 3962-3979. [https://doi.org/10.1039/C5LC00716J]
Chen, A., Pan, T., 2014, Manually Operatable On-chip Bistable Pneumatic Microstructures for Microfluidic Manipulations, Lab on a Chip, 14 3401-3408. [https://doi.org/10.1039/C4LC00540F]
Dimov, I. K., Basabe-Desmonts, L., Garcia-Cordero, J. L., Ross, B. M., Riccoa, A. J., Lee, L. P., 2011, Stand-alone Self-powered Integrated Microfluidic Blood Analysis System (SIMBAS), Lab on a Chip, 11 845-850. [https://doi.org/10.1039/C0LC00403K]