한국생산제조학회 학술지 영문 홈페이지

Current Issue

Journal of the Korean Society of Manufacturing Technology Engineers - Vol. 29 , No. 5

[ Papers ]
Journal of the Korean Society of Manufacturing Technology Engineers - Vol. 29, No. 5, pp.370-377
Abbreviation: J. Korean Soc. Manuf. Technol. Eng.
ISSN: 2508-5107 (Online)
Print publication date 15 Oct 2020
Received 10 Sep 2020 Revised 13 Oct 2020 Accepted 14 Oct 2020
DOI: https://doi.org/10.7735/ksmte.2020.29.5.370

3차원 마이크로 세포칩 제작을 위한 3차원 연속 레이저 스캐닝 방법
최재원a ; 이지선a ; 도한명b ; 김영철b ; 박지용a ; 손용a ; 김경지c, d ; 이권재e ; 안정희d ; 하철우a, *

Three-dimensional Continuous Laser Scanning Method for Three-dimensional Microcell Chip Application
Jae-Won Choia ; Jisun Leea ; HanMyeong Dob ; Young Choel Kimb ; Jiyong Parka ; Yong Sona ; Gyeong-Ji Kimc, d ; Kwon-Jai Leee ; Jeung Hee And ; Cheol-Woo Haa, *
aIntelligent Manufacturing R&D Department, Korea Institute of Industrial Technology
bInstitue of Advanced Convergence Technology, Kyungpook National University
cDepartment of Biomedical Engineering, Sogang University
dDepartment of Food and Nutrition, KC University
eDepartment of H-LAC, Daejeon University
Correspondence to : *Tel.: +82-32-8084-8827 E-mail address: cwha@kitech.re.kr (Cheol-Woo Ha).

Funding Information ▼

Abstract

Nanostereolithography induced by a femtosecond laser is widely used for fabrication of three-dimensional (3D) microstructures with submicron resolutions. In this study, we propose a 3D continuous laser scanning method for an effective direct writing of 3D microstructures. The advantages of the 3D continuous laser scanning method are analyzed by considering its high resolution, time economy, and fabrication effectiveness. As the 3D continuous laser scanning is an efficient manufacturing method, which can immediately respond to a complex 3D structure, it could be used for various applications including platforms for cell culture, metamaterials, and functional sensors. In this paper, the 3D open cell structure was fabricated and cells are cultured on the structure for microcell chip application.


Keywords: Nano-stereolithography, Three-dimensional continuous laser scanning, Two-photon polymerization, High resolution microstructure

Acknowledgments

본 연구는 2020년도 한국생산기술연구원 내부과제(UI200020)의 지원과 산업통상자원부의 산업기술혁신사업(20012434) 및 산업통상자원부와 한국산업기술진흥원의 지역산업거점기관지원사업(R0004072)으로 수행된 연구결과입니다.


References
1. Lim, T. W., Park, S. H., Yang, D. Y., Kong, H. J., Lee, K. S., 2006, Direct Single-layered Fabrication of 3D Concavo-convex Patterns in Nano-stereolithography, Appl. Phys. A Mater. Sci. Process, 84:4 379-383.
2. Lim, T. W., Son, Y., Yang, D. Y., Kong, H. J., Lee, K. S., Park, S. H., 2008, Continuous Scanning Method for Improvemnt of Precision and Fabrication Efficiency of Two-photon Stereolithography, Trans. Korean Soc. Mech. Eng. A., 32:5 396-401.
3. Wang, X., Wei, Z., Baysah, C. Z., Zheng, M., Xing, J., 2019, Biomaterial-based Microstructures Fabricated by Two-photon Polymerization Microfabrication Technology, RSC Adv., 9:59 34472-34480.
4. Hilton, P., 2000, Rapid Tooling: Technologies and Industrial Applications, Marcel Dekker, New York.
5. Ha, C. W., Prabhakaran, P., Lee, K. S., 2019, Versatile Applications of 3D Objects Fabricated by Two-Photon-Initiated Polymerization, MRS Communications, 9:1 53-66.
6. Varadan, V. K., Jiang, X., Varadan, V. V., 2001, Microstereolithography and other Fabrication Techniques for 3D MEMS, Wiley, New York.
7. Zhang, X., Jiang, X. N., Sun, C., 1999, Micro-stereolithography of Polymeric and Ceramic Microstructures, Sensors Actuators, A Phys. 77:2 149-156.
8. Maruo, S., Kawata, S., 1998, Two-Photon-Absorbed Near-Infrared Photopolymerization for Three-Dimensional Microfabrication, J. Microelectromechanical Syst., 7:4 411-415.
9. Kawata, S., Sun, H. B., Tanaka, T., Takada, K., 2001, Finer Features for Functional Microdevices, Nature., 412:6848 697-698.
10. Zheng, L., Kurselis, K., El-Tamer, A., Hinze, U., Reinhardt, C., Overmeyer, L., Chichkov, B., 2019, Nanofabrication of High-Resolution Periodic Structures with a Gap Size Below 100 nm by Two-Photon Polymerization, Nanoscale Res Lett.
11. Serbin, J., Egbert, A., Ostendorf, A., Chichkov, B. N., Houbertz, R., Domann, G., Schulz, J., Cronauer, C., Fröhlich, L., Popall, M., 2003, Femtosecond Laser-induced Two-Photon Polymerization of Inorganic–organic Hybrid Materials for Applications in Photonics, Opt. Lett., 28:5 301.
12. Deubel, M., Von Freymann, G., Wegener, M., Pereira, S., Busch, K., Soukoulis, C. M., 2004, Direct Laser Writing of Three-dimensional Photonic-crystal Templates for Telecommunications, Nat. Mater., 3:7 444–447.
13. Trautmann, A., Götzendorfer, B., Walther, T., Hellmann, R., 2018, Scaffolds in a Shell–a New Approach Combining One-Photon and Two-Photon Polymerization, Opt. Express., 26:23 29659.
14. Frenzel, T., Kadic, M., Wegener, M., 2017, Three-dimensional Mechanical Metamaterials with a Twist, Science, 358:6366 1072-1074.
15. Vangelatos, Z., Komvopoulos, K., Grigoropoulos, C. P., 2019, Vacancies for Controlling the Behavior of Microstructured Three-dimensional Mechanical Metamaterials, Math. Mech. Solids., 24:2 511-524.
16. Ha, C. W., Yang, D. Y., 2014, Rotational Elastic Micro Joint based on Helix-augmented Cross-spring Design for Large Angular Movement, Opt. Express, 22:17 20789.
17. Liberale, C., Cojoc, G., Candeloro, P., Das, G., Gentile, F., De Angelis, F., Di Fabrizio, E., 2010, Micro-optics Fabrication on Top of Optical Fibers Using Two-Photon Lithography, IEEE Photonics Technol. Lett., 22:7 474–476.
18. Gissibl, T., Thiele, S., Herkommer, A., Giessen, H., 2016, Two-Photon Direct Laser Writing of Ultracompact Multi-lens Objectives, Nat. Photonics., 10:8 554–560.
19. He, Z., Tan, G., Chanda, D., Wu, S.T., 2019, Novel Liquid Crystal Photonic Devices Enabled by Two-Photon Polymerization [Invited], Opt. Express, 27:8 11472.
20. Kμmi, G., Yanez, C. O., Belfield, K. D., Fourkas, J. T., 2010, High-speed Multiphoton Absorption Polymerization: Fabrication of Microfluidic Channels with Arbitrary Cross-sections and High Aspect Ratios, Lab Chip., 10:8 1057-1060.
21. Choi, H. W., Yoon, S. C., Ma, J. K., Bang, D. W., 2014, Fabrication of Micro-reactor by 3D Printing Machine, J. Korean Soc. Manuf. Technol. Eng., 23:3 218-222.
22. Park, C., Kim, M. H., Hong, S. M., Go, J. S., Shin, B. S., 2015, A Study on th Comparision Mechanical Properties of 3D Printing Prototypes with Laminating Direction, J. Korean Soc. Manuf. Technol. Eng., 24:3 334-341.
23. Schizas, C., Karalekas, D., 2010, Mechanical Characteristics of an Ormocomp® biocompatible Hybrid Photopolymer, J. Mech. Behav. Biomed., 4:1 99-106.
24. Ovsianikov, A., Schlie, S., Ngezahayo, A., Haverich, A., 2007, Two-Photon Polymerization Technique for Microfabrication of CAD-designed 3D Scaffolds from Commercially Available Photosensitive Materials, J. Tissue Eng., Regen. M., 1:6 443-449.
25. Schlie, S., Ngezahayo, A., Ovsianikov, A., Fabian, T., Kolb, H., Haferkamp, H., Chichkov, B. N., 2017, Article Metrics Related Articles Cite Share Request Permissions Explore More Download PDF Three-Dimensional Cell Growth on Structures Fabricated from ORMOCER® by Two-Photon Polymerization Technique, J. Biomater. Appl., 22:3 275-287.
26. Richter, B., Hahn, V., Bertels, S., Claus, T. K., Wegener, M., Delaittre, G., Barner-Kowollik, C., Bastmeyer, M., 2017, Guiding Cell Attachment in 3D Microscaffolds Selectively Functionalized with Two Distinct Adhesion Proteins, Adv. Mater., 29:5 1604342.
27. Klein, F., Richter, B., Striebel, T., Franz, C. M., Freymann, G., Wegener, M., Bastmeyer, M., 2011, Two‐Component Polymer Scaffolds for Controlled Three‐Dimensional Cell Culture, Adv. Mater. J., 23:11 1341-1345.
28. Lee, K. J., An, J. H., Shin, J. S., Ha, C. W., Son, Y., Seok, J. S., Lee, K, S., 2017, Evaluation of Anticancer Drug in a Polymer 3D Cell Chip, Opt. Mater. Express, 7:8 291941.
29. Lee, K. J., An, J. H., Ha, C. W., Son, Y., Yang, D. Y., Chae, H. N., Lee, K. S., Choi, J. W., 2016, 3D Hierarchical, Pyramid-Based Cancer Cell Chip for the Detection of Anticancer Drug Effects, J. Biomed. Nanotechnol, 12 1-14.

Jae-Won Choi

Associate Research in Department of Intelligent Manufacturing R&D Department, Korea Institute of iIndustrial Technology.His research interest is micro 3D Printing.

E-mail: jw0910@kitech.re.kr

Jisun Lee

Researcher in Department of Intelligent Manufacturing R&D Department, Korea Institute of iIndustrial Technology.Her research interest is Additive Manufacturing.

E-mail: jslee326@kitech.re.kr

HanMyeong Do

Associate Research in Institue of Advanced Convergence Technology, Kyungpook National University.His research interest is Additive Manufacturing.

E-mail: oneman@iact.or.kr

Young Cheol Kim

Research Professor in Institue of Advanced Convergence Technology, Kyungpook National University.His research interest is Additive Manufacturing.

E-mail: yckim@knu.ac.kr

Jiyong Park

Senior researcher in Department of Intelligent Manufacturing R&D Department, Korea Institute of iIndustrial Technology.His research interest is Additive Manufacturing.

E-mail: j.park@kitech.re.kr

Yong Son

Principle researcher in Department of Intelligent Manufacturing R&D Department, Korea Institute of iIndustrial Technology.His research interest is Additive Manufacturing.

E-mail: sonyong@kitech.re.kr

Gyeong-Ji Kim

Doctor’s Course Student in Department of Biomedical Engineering, Sogang University.Her research interest is Cell Biology.

E-mail: kgj8495@hanmail.net

Kwon-Jai Lee

Assistant Professor in Department of H-LAC, Daejeon University.His research interest is Nano Material Manufacturing.

E-mail: kjlee@dju.kr

Jeung Hee An

Associated Professor in Department of Food and Nutrition, KC University.Her research interest is Cell Biology.

E-mail: anjhee@hanmail.net

Cheol-Woo Ha

Senior researcher in Department of Intelligent Manufacturing R&D Department, Korea Institute of iIndustrial Technology.His research interest is Two-photon sterolithogarphy.

E-mail: cwha@kitech.re.kr