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Journal of the Korean Society of Manufacturing Technology Engineers - Vol. 29 , No. 1

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Journal of the Korean Society of Manufacturing Technology Engineers - Vol. 29, No. 1, pp. 51-58
Abbreviation: J. Korean Soc. Manuf. Technol. Eng.
ISSN: 2508-5107 (Online)
Print publication date 15 Feb 2020
Received 03 Dec 2019 Revised 12 Dec 2019 Accepted 18 Dec 2019
DOI: https://doi.org/10.7735/ksmte.2020.29.1.51
절연파괴 현상을 구동력으로 하는 마이크로젯 인젝터 개발
함휘찬^a ; 김용현^a ; 육승근^b ; 여재익^a^{, *}


Dielectric Breakdown Induced-microjets Used for Intradermal Drug Delivery
Hwi-chan Ham^a ; Yong-hyun Ghymn^a ; Seung-keun Yook^b ; Jai-ick Yoh^a^{, *}
aDepartment of Mechanical and Aerospace Engineering, Seoul National University
bHanwha Systems Co., Ltd.
Correspondence to : ^*Tel.: +82-2-880-9334 E-mail address: jjyoh@snu.ac.kr (Jai-ick Yoh).



Funding Information ▼ Hanwha Systems

Abstract

Drug delivery via microjets is a method that can potentially overcome the disadvantages of conventional needle injections. We implemented a microjet injection system that operates with spark-generated bubbles. The system consists of three components: a battery, power supply system, and microjet injector, which allows 10–20 discharges and microjet injections per second. In order to increase discharge efficiency, the circuit elements and electrode shapes were optimized and the flow inside the discharge chamber was operated to minimize the influence of metal colloids generated by electrode erosion. The microjet ejection was captured by a high-speed camera to correlate the energy of the spark discharge with microjet characteristics in order to make the system suitable for transdermal drug penetration.


Keywords: Microjet, Dielectric breakdown, Spark discharge, Needle-free, Drug-delivery

Acknowledgments

이 논문은 2019년도 한화시스템(주) 의 재원을 지원받아 수행된 연구임.

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Hwi Chan Ham

Ph.D. Candidate in the Department of Mechanical & Aerospace Engineering, Seoul National University.His research interest is underwater spark discharge and pulsed flow.

E-mail: hamn2012@snu.ac.kr

Yong hyun Ghymn

Visiting researcher in the Institute of Advanced Machines and Design, Seoul National University.He is interested in high voltage physics, biomedical engineering and fabrication of IoT devices.

E-mail: udtseal48130@snu.ac.kr

Seung-keun Yook

Senior Engineer in Land R&D Center, Hanwha System.

E-mail: skyook@hanwha.com

Jai Ick Yoh

Professor in the Department of Mechanical & Aerospace Engineering, Seoul National University.His research interest includes physics of matters at extreme states.

E-mail: jjyoh@snu.ac.kr