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Journal of the Korean Society of Manufacturing Technology Engineers - Vol. 28 , No. 3

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Journal of the Korean Society of Manufacturing Technology Engineers - Vol. 28, No. 3, pp. 166-175
Abbreviation: J. Korean Soc. Manuf. Technol. Eng.
ISSN: 2508-5107 (Online)
Print publication date 15 Jun 2019
Received 05 Apr 2019 Revised 09 May 2019 Accepted 28 May 2019
DOI: https://doi.org/10.7735/ksmte.2019.28.3.166
하이드로겔과 미세유체채널을 이용한 단속적 약물 공급소자
장웅기^a ; 서영호^b ; 김병희^a^{, b}^{, *}


Intermittent Drug Supply Device Using Hydrogel and Microfluidic Channel
Woong Ki Jang^a ; Young Ho Seo^b ; Byeong Hee Kim^a^{, b}^{, *}
aKangwon Institute of Inclusive Technology, Kangwon National University, 1, Kangwondaehakgil, Chunchon, Gangwon, 24341, Korea
bDivision of Mechanical & Biomedical, Mechatronics, and Materials Science and Engineering, Kangwon National University, 1, Kangwondaehakgil, Chunchon, Gangwon, 24341, Korea
Correspondence to : ^*Tel.: +82-33-250-6374 Fax: +82-33-259-5548 E-mail address: kbh@kangwon.ac.kr (Byeong Hee Kim).



Funding Information ▼ Ministry of Science and ICT National Research Foundation of Korea 2015R1A5A1037668 Ministry of Trade, Industry and Energy Korea Institute for Advancement of Technology P0002092

Abstract

In this study, we propose a device that uses the expansive force of a hydrogel to inject a small amount of a drug over a long duration. The proposed microfluidic drug injection device has a hydrogel in the injection chamber. The expansive force of the hydrogel provides the injection pressure to control the drug injection period, time required for supplying water to the hydrogel, and hydrogel expansion time. The use of a hydrogel is difficult due to its powdery texture. Hence, the hydrogel was mixed with polydimethylsiloxane (PDMS) and converted into hydrogel disks. A stop valve was also designed to generate flow resistance in the microfluidic device, which supplies water to the hydrogel. The drug injection intermittently supplied the hydrogel’s expansive force along with the drug, with ~2.1 ㎕ of the drug being administered. Results demonstrate that the hydrogel expansive force can be used to achieve intermittent drug supply.


Keywords: Drug delivery dystem, Infusion pump, Hydrogel, Micro channel, Time delayed micro shape

Acknowledgments

본 연구는 2015년도 정부(과학기술정보통신부)의 재원으로 한국연구재단의 지원을 받아 수행된 기초연구사업(No. 2015R1A5A1037668)이며, 2019년도 정부(산업통상자원부)의 재원으로 한국산업기술진흥원의 지원을 받아 수행된 연구임(P0002092, 2019년 산업전문인력역량강화사업).

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